Title: Nicardipine vs Labetalol for Blood Pressure Management in the ED
题目：尼卡地平和拉贝洛尔在急诊科处理高血压的作用
Author 作者: Bryan Hayes
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A recent randomized trial compared nicardipine as a continuous infusion to labetalol boluses to determine which one was more effective at lowering blood pressure to a target range within 30 minutes.
一个新的随机临床试验对持续静脉点滴尼卡地平和静脉缓推拉贝洛尔在降压作用进行了比较，以确定谁能在30分钟内将血压控制在理想范围内。
Median initial SBP for the 226 patients was 212 mm Hg. Within 30 minutes, nicardipine patients more often reached target range than labetalol (91.7 vs. 82.5%, P = 0.039). Of 6 BP measures (taken every 5 minutes) during the study period, nicardipine patients had higher rates of five and six instances within target range than labetalol (47.3% vs. 32.8%, P = 0.026).
226个病人的平均初始收缩压（SBP）为212mmHg。在30分钟内，与拉贝洛尔（82.5％）比较，较多的接受尼卡地平（91.7％，p=0.039）的病人达到了理想目标。在试验时间内的6个血压测定（每5分钟一次），尼卡地平病人有5－6次达到理想范围的频率要明显高于拉贝可尔病人（47.3％ 对32.8％， p＝0.026）。
What this means: Nicardipine is a reasonable choice for patients needing acute lowering of blood pressure (e.g., ischemic stroke with tPa).  Nicardipine seems to achieve faster and smoother lowering of blood pressure than labetalol therapy with less blood pressure readings outside the target range.
这说明：尼卡地平在需要紧急使血压降低时（如缺血性脑梗塞需要tPA治疗）。尼卡地平要比拉贝洛尔在降压方面起效快，平稳，血压值很少超出理想值范围内。
References 参考文献

Peacock WF, Varon J, Baumann BM, et al. CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department. Crit Care 2011;15(3):R157. Epub 2011 Jun 27.