Title: Optimal Timing of Coronary Invasive Strategy in NSTEMI
题目：对于非ST段抬高心肌梗塞（NSTEMI）冠状动脉介入治疗措施的最佳时间
Author 作者: Semhar Tewelde

International guidelines recommend early invasive strategy (<24hrs) for patients with NSTEMI w/high risk factors defined by a GRACE score >140
国际指南建议对GRACE指标超过140的高危险NSTEMI病人，要进行早期的介入治疗（24小时内）。
A recent meta-analysis based on 7 RCTs & 4 observational studies demonstrated an inconclusive survival benefit with an early invasive strategy 
一个最新的对7个随机临床研究和4个观察报告的综合文献分析，指出早期的介入治疗并不能明确的改善预后。
Heterogeneity across multiple studies including timing of intervention, definition of MI, patients' risk profiles, major bleeding, and sample size make the interpretation of survival results difficult
这些研究在治疗时间，心肌梗塞的定义，病人的危险因素，大出血，和样本量的不一致性使对生存率的分析造成困难。
Based on the most recent data the optimal timing of intervention remains unclear and a more definite RCT is warranted to guide clinical practice
依据最新的资料，介入治疗的最佳时间还不明了，需要一个相当明确的随机临床实验来指导临床实践。
 
References 参考文献
Navarese E, et al. Optimal Timing of Coronary Invasive Strategy in Non-ST-Segment Elevation Acute Coronary Syndromes. Ann Intern Med. 2013;158:261-270.