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Title: Coronary CT Angiography
题目:冠状动脉CT血管造影(CCTA)
Author 作者: Semhar Tewelde, MD
I. CCTA vs. other tests CCTA与其它检查的比较:
a. Myocardial perfusion scan & stress echo have sensitivity of 85-90% and
specificity of 75-80%
心肌灌注扫描和超声负荷试验的敏感性是85-90%,特异性是75-80%。
b. Negative CCTA has nearly 100% negative predicative value
隐性CCTA的阴性预测值几乎接近100%
c. Radiation of CCTA 2-5mSv (5-10mSv for other nuclear medicine studies)
CCTA的放射性为2-5毫希沃特(其它的同位素试验为5-10)
d. At large academic centers, cost is equal
在大型学术中心,收费标准一样
II. Multicenter safety study 多中心安全研究1
a. Primarily looked at safety compared to other methods
主要是与其它方法在安全方面进行比较
b. 5 centers, 2009-2011, 1370 total patients
5个中心,2009-2011年,1370个病人
c. Patients age >30, TIMI 0-2
病人年龄超过30,TIMI分数在0-2
d. If CCTA negative (<50% stenosis), <1% had MI/death at 30 days (same as traditional group)
如CCTA阴性(既小于50%狭窄),不到1%的病人会在30天内发生心肌梗塞/死亡(与对照组一样)
III. Multicenter LOS study 多中心住院时间研究2
a. Primary outcome was LOS
主要指标是住院时间
b. 9 hospitals, 2010-2012, total ~1000 patients
9个医院,2010-2012年,一共有大约1000病人
c. Patients age 40-74
病人年龄在40-74
d. CCTA had 7.6h shorter LOS (average d/c within 8 hours of presentation to ED)
CCTA缩短了住院时间7.6个小时(从急诊接诊到出院平均时间为8小时以内)
IV. BOTTOM LINE 要点
a. Only supporting evidence for CCTA is in patients with TIMI score 0-2
所有支持CCTA应用的证据都来源于TIMI分数在0-2的病人(危险因素轻中度)
b. Radiation from CCTA is less than other nuclear medicine studies
CCTA的放射性要低于其它的同位素检查
c. Cost of CCTA is equal to other testing
CCTA的费用于其它检查一样
References 参考文献:
1. Litt HI, Gatsonis C, Snyder B et al. CT angiography for safe discharge of patients with possible acute coronary syndromes. NEJM 2012;366(15):1393-403.
2. Hoffmann U, Truong QA, Schoenfeld DA et al. Coronary CT angiography versus standard evaluation in acute chest pain. NEJM 2012;367(4):299-308.