Title: Takayasu Arteritis (TA)
题目：多发性大动脉炎
Author 作者: Semhar Tewelde
 
Takayasu arteritis (TA) is a granulomatous vasculitis that affects the aorta and its major branches
多发性大动脉炎（TA）是累及主动脉及其大分枝的肉芽肿性血管炎
Involvement of the aortic arch is associated w/CNS symptoms, claudication, absent peripheral pulses, and cardiac manifestations
主动脉弓的病变会产生中枢神经系统症状，间歇性跛行，末梢动脉丧失，和心脏表现
The EULAR/PReS consensus criteria for Dx of childhood TA requires characteristic angiographic abnormalities of the aorta plus 1 of the following:
欧洲抗风湿病联盟(EULAR)/欧洲儿童风湿病学会(PRES)诊断儿童多发性大动脉炎需要特异性的主动脉造影异常，同时包括下列一项：
Absent peripheral pulses or claudication 末梢动脉丧失或间歇性跛行
Blood pressure discrepancy in any limb 任何肢体间的血压差异
Bruits 血管杂音
Hypertension 高血压
Elevated acute phase reactants 急性期反应因子增加

Gold standard for Dx is angiography; however, CT and MR angiograms are less invasive and can detect inflammation & luminal diameter changes 
确诊的金标准是动脉造影，但CT和MR创伤性低，可以发现炎症和腔内径的改变
Tx is challenging, steroids may induce remission in up to 60%
治疗是具有挑战性的，激素可能会缓解大约60％的病人
 
References 参考文献：
Weiss P, et al. Pediatric vasculitis. The Pediatric clinics of North America. April 2012:59;2:407-423.