Title: Procainamide Dosing
题目：普鲁卡因胺剂量
Author 作者: Ellen Lemkin

ACLS recommendation for procainamide in tachycardic rhythms is:
ACLS对普鲁卡因治疗心动过速的建议是：
Loading dose 20 mg/minute (up to 50 mg/minute for more urgent situations) until:
负荷剂量为20毫克/分钟（在更紧迫的情况下可高达50毫克/分钟），直到：
Arrhythmia is controlled
心律失常得以控制
Hypotension occurs
出现低血压
QRS complex widens by 50% of its original width
QRS波比基础变宽达50％
or total of 17 mg/kg is given
或总剂量已达17毫克/公斤体重
Maintenance infusion is 1 to 4 mg/min.
 维持剂量为1 〜4毫克/分。

An easier method for dosing acute onset atrial fibrillation in stable patients was used in the Ottawa Aggressive Protocol, in which they administered 1 gm over 60 min, which was interrupted if BP < 100 mmHg.
一个更简单的治疗稳定的急性发作房颤病人的给药方法是渥太华快速方案，他们在60分钟内给1克，如果血压< 100毫米汞柱，就要停止。
 
A strategy for treating stable monomorphic VT with procainamide used:
用普鲁卡因胺治疗稳定的单形性室速的方案：
100 mg IV over 1-2 minutes, repeat as necessary until an endpoint of
1-2分钟内静脉给100毫克，必要时可重复，直到下列任何一项出现：
Termination of tachycardia
心动过速终止
Drug induced hemodynamic deterioration
药物引起的血流动力学恶化
Completion of 800 mg maximal dose
已用到800毫克的最大剂量
If no slowing of the tachycardia occurred with a dose of 400 mg, the administration was ceased.
如果400毫克后心动过速还没有慢下来，就要停止给药。

References 参考文献：
1. Steil IG, Clement CM, Perry JJ et al. Association of the Ottawa Aggressive Protocol with rapid discharge of emergency department patients with recent-onset atrial fibrillation or flutter. CJEM 2010;12(3):181-91.
2. Komura S, Chinushi M, Furushima H. et al. Efficacy of Procainamide and Lidocaine in Terminating Sustained Monomorphic Ventricular Tachycardia. Circulation May 2010 Vol 72