Title: Ondansetron and QT Prolongation
题目：昂丹司琼与QT间期延长
Author 作者: Fermin Barrueto
翻译：李 辉 校对：肖 锋


Ondansetron is a highly effective anti-emetic that, since it has gone generic, is also quite inexpensive. There have been some reports of QT prolongation and cardiac arrhythmias especially with the high-dose 32mg IV dose for chemotherapy patients.
昂丹司琼是一种高效的止吐药，由于过了保护期，也很便宜。现已有一些关于昂丹司琼导致化疗患者QT间期延长和心律失常的报道，特别是高剂量32mg静脉注射时。
Is still safe in our ED population? A large systematic review was done in this month's Ann Emerg Med July 2014,p19-31.
昂丹司琼在急诊人群中的使用依旧安全吗？本月（2014年7月 , 19-31页）急诊医学年鉴刊登了一项大型的系统综述。
Take Home Points 关键点：
1) No reports of arrhythmia associated with single dose administration identified
1）没有研究指出心律失常与单次使用昂丹司琼有关。
2) 80% of 60 unique reports were IV
2）60例个案报道中80%为静脉注射。
3) 83% had significant PMH or already on a QT prolonging drug
3）83%的报道为患者有既往史或已在服用导致QT间期延长的药物。
Conclusion: Ondansetron doesn't warrant routine EKG or electrolyt screening in oral administration. High dose IV and High Risk patients do require more vigilance with EKG and electrolyte screening.
结论：口服昂丹司琼不需要常规行心电图或电解质检查。经静脉高剂量以及高危患者确实需要警惕心电图及电解质。