Title: Can Hydroxocobalamin be administered via intraosseous access for acute cyanide toxicity?
题目：羟钴胺能否通过骨髓内途径给药治疗急性氰化物中毒？
Author 作者: Hong Kim
翻译：郑辛甜 校对：肖锋

Hydroxocobalamin is an effective cyanide antidote when administered intravenously. Although intraosseous (IO) access is often used in critically ill patients with difficult or delayed IV access, the efficacy of IO administration has not been investigated until recently.
静脉注射羟钴胺是一种有效的氰化物解毒方式。尽管骨髓内给药在静脉给药困难或有延误的危重症患者中较为常用，但是其有效性直到近期才有研究。
In a recent randomized animal study, acute cyanide toxicity was induced in two groups of swine where 150 mg/kg Hydroxocobalamin was administered via IV vs. IO. The survival rate, reversal of hypotension, and laboratory results were similar between the IV and IO group.
在一项最近的随机动物实验中，两组诱导急性氰化物中毒的猪分别通过静注或骨髓内给予150 mg/kg的羟钴胺。两组的存活率、低血压逆转以及实验室监测指标等差异无统计学意义。
The finding of this study suggest that IO administration of Hydroxocobalamin is as efficacious as IV administration and its administration in acute cyanide toxicity should not be delayed due to lack of IV access when IO access is available.
这些研究提示骨髓内给羟钴胺和静注一样有效，当急性氰化物中毒无法通过静注给药但可放置髓内针时，不要延误治疗。

References 参考文献：
Bebarta VS, Pitotti RL, Bondreau S and Tanen DA. Intraosseus versus intravenous infusion of hydroxocobalamin for the treatment of acute severe cyanide toxicity in a swine model. Academic Emergency Medicine. 2014; 21 (11): 1203-1211.